Variant of the Lewis lung carcinoma (3LL-HH), B16 melanoma, a rat nephroblastoma (RWT-M), and a human colon carcinoma xenograft (HCR25) in immunosuppressed mice were used to study the effects of Avemar alone and Avemar plus vitamin C on tumor growth and metastasis. Effects on metastases were studied both with the primary tumors intact and after their surgical removal. Vitamin C alone had a significant inhibitory effect on metastases in some of these tumor models but not in others. However, combined treatment with Avemar plus vitamin C administered simultaneously profoundly inhibited metastases in all tumor models. Interestingly, in some tumor models, treatment with Avemar alone had a greater inhibitory effect on metastasis formation than did Avemar plus vitamin C. These observations suggested that when administrated together (in the form of the synchronous combined treatment) the two compounds (Avemar and vitamin C) are mutually and favorably influence each other’s effect. (Hidvégi et al., 1998)
