AVEMAR對於發炎前期細胞素生成及ras參與之細胞活化的協同作用
Telekes A, Kiss-Toth E, Nagy T, Qwarnstrom EE, Kusz E, Polgar T, Resetar A, Dower SK, Duda E. Synergistic effect of Avemar on proinflammatory cytokine production and ras-mediated cell activation, Ann N Y Acad Sci. 2005 Jun;1051:515-28
英文摘要
Macrophages activated by lipopolysaccharide and/or phorbol esters exhibited high sensitivity to Avemar, a fermented wheat germ extract. Avemar synergized with lipopolysaccharide and PMA in the induction of the transcription of cytokine genes and release of inflammatory cytokines. At higher concentrations the preparation had a significant negative effect on the proliferation and survival of activated myeloid cell types. Avemar treatment induced the synthesis of ICAM-1 and synergized with the ICAM-inducing effect of TNF, but had no effect on VCAM-1 expression on microvascular endothelial cells. The effect of Avemar on signaling pathways, which are involved in cell activation was studied on HeLa cells as a model system. Avemar treatment increased the activity of stress kinases in a concentration-dependent way, resulting in the activation of AP-1 transcription factor. NF-kappa B-sensitive reporters were also activated by Avemar; in contrast, no effect of the preparation was observed on PKA-sensitive signaling pathways.
